It is possible and would be very easy to do. I used VCarve Pro to do mine but in a simple form you could make a 2 foot X 2 foot grid of holes and cut them in the first two feet of the top. Mark every two feet down the top and reference that point to the zero on your machine.
When I cut mine, I simple zeroed the machine to the very front of the wasteboard and then lined up the 2 foot marks and cut each tile that VCarve Pro measured for me on the 2X8 foot top. VCarve just makes it much easier especially for those sizes that are not as convenient as this would be.