Will can probably say how long one can do this, but you can pause the machine and continue the next day. It’s not good for the stepper motors to have them on “standing still” forever (stepper motors use the most power holding still under a load)… but “forever” I take as weeks and months; overnight might be not too bad.
In theory you can also turn things off and re-home and continue, but homing switch repeat accuracy is good, but not nearly as good as stepper motor steps, so you run a bit of risk doing that that things shift a little… might be ok in roughing, but I’d not do that with finishing passes