Yes. I have been using Fusion and my Shapeoko together for years, and while I did play with machine profile/simulation feature when it came out, it was only fun for about 5 minutes and I soon went back to basics: a Shapeoko-compatible post-processor is the only mandatory thing to have setup.
Our own @neilferreri’s post is my alltime favorite, available here
(not a broken link, since it was uploaded to this site)
just use “Simulate” instead of “Simulate with machine” and you are good to go, i.e. figuring out how your toolpaths may or may not hit your stock/piece, as long as you manage separately the potential conflicts between your job and the machine limits (max machinable area, max stock height you can manage etc)