Interesting about 5x10 sheets of MDF. What did you use for the shelf at the bottom front?
I will note that if you’re willing to snug the machine up against the front and allow for a bit of overhang at the back (it’s unsupported/not touching the table anyway), 48" can be made to work for a 4x4, and 24" for a 4x2:
The hose seems fine to me, so long as it doesn’t drag onto the gantry and interfere with machine motion.