Its often a good idea to prep hardware before using a thread locking compound. Alcohol or otherwise quick flashing solvent that does not leave substantial petroleum distillates, or purchase a prep specific treatment. I doubt very much that the Shapeoko would release something like Loctite 262.
I professionally wrench on all manner of hardware. Just finished installing a pair of CAT C12’s yesterday. On site I typically use nothing more than Permatex Anaerobic Gasket maker on uncleaned hardened hardware. I have little concern, i.e no concern, that it will back out. In my shop, I use various thread locking compounds on cleaned hardware, no concern. On small hardware, something like Red 262 would require a soldering iron or induction hardware heater to safely remove.
Anyway, my shapeoko is assembled with Blue 249, a medium strength thread locker. Nothing has ever backed out. and a sharp hex is required for disassembly.