My local (big name company I can’t mention) speaker manufacturer has had me making prototype speaker boxes for about ten years. This time he wanted some 4-foot tall towers. They are too large for my Shapeoko to do in a single cut so I had to adapt a 2-file strategy and it worked great.
One speaker hole was cut then the entire board was shifted on the machine to accommodate the second group of speakers. The cnc is not really required for two speakers, but should he ever want another similar design, the exercise will prove invaluable.
There are one small and one large square hole for horns and two matching woofer holes. Also a small hole on the back for the connector. 3/4 MDF, 48 x 12 x 12 finished size. He was quite happy.