The only catch then would be the reduced X travel on the left side, which means the Sweepy/hose would collide with the left rail when e.g. using the NW, W, and SW quick positions with the default CM setup.
That’s a significant part of the work area becoming unusable, but if you do not care for that it is possible to adjust the GRBL parameters / work area dimensions to reduce it.
Another Newbie here. I have had mine mounted on the left since purchase. My elementary projects have not needed the full size of my table so that has not been an issue. What I have noticed is that it seems to interfere with my clamping because I tend to clamp my projects on the left and right.