From what I’ve read and tried myself drilling is a no-no on this class of high speed spindle CNC machine.
On a big mill running at 1,000 RPM a big drill is a good way to hog out a lot of material quickly but you’ll need solid carbide drills to go at anything near the speed our spindles run at, they’re not cheap.
Also, drilling will still give you a messy hole because drills cut a triangular hole generally with tear out on one or both sides.
Milling a hole using the bore CAM toolpath in Fusion lets you cut clean holes in almost anything, but you need a smaller cutter than the hole you plan to cut so that it can spiral down the hole cleanly. I’ve put 4.6mm holes in the edge of 5mm Acrylic like this without blow-out. If you want counterbores at the top etc. then a contour toolpath works well for those.
If you’re using Fusion then I’d suggest you try a roughing and then a finishing toolpath, then you can use an upcut cutter which will clear chips well for the roughing toolpath and then come back with a downcut or compression cutter to do the finishing. There’s also plently of low helix upcut cutter out there, but beware, they don’t always clear chips as well as the high helix cutters.
Have a look at this thread;
For some examples of different cutters and roughing / finishing strategies in ply.
HTH