I am not a pro with CNC, I just make mistakes and try to learn from them. Others will disagree with me and they are probably more correct than I am. Plywood, by structure, is an interesting material to mill. Every cut into two or more layers is both a rip and a crosscut milling with interfering adhesive. I mill a lot of plywood. I set my depth of cut for 0.10 inches. For each bit I set my feed rate for about 90% of what the default is for that bit and then I watch and listen to the milling process. Carbide Motion allows you to slow or speed up the feed rate. If the router or spindle is excessively burdened, I can slow the feed rate down. It it is running easily, I can increase it, but usually don’t.
End mills are going to act differently. If you accept (example values) 40 inches per minute with a depth of cut of 0.10 inches per pass and use the same #6 speed setting on your router, the fastest, you may get a great cut with an up cut end mill, a fair cut with a straight cut mill, and a lousy cut with a down cut, swap bits and cut qualities as you like, they are all different.
And, since the actually plywood is the key, oak, luan, pine, CDX, etc. hard answers are tough to provide. However, watch out for plywoods where the adhesive gunks up the bit. Bits need to be clean and undamaged. Plywood is a tough cut and bits burn fairly easily in it due to its construction.
I use Vectric and Carbide Create and prefer to keep my measurements off the top of the material. With that said, make sure you overhang the probe block when you are supposed to and it is placed on top of the material when it is supposed to be. I love the graphics in Carbide Motion for this. I try to place the probe block in the same location each time - consistency.
The design looks great. I like the “finger grab areas.” If you wanted design comments, I think I would join the two straight cut finger indents on the right two straight pockets together. Should finger indent pockets be slightly deeper than the tool pocket? Hmmm.
Good luck and let us know how it turns out.