No problems with clearance on X or Y steppers. Not sure on the standard belt driven Z (I have the Z-Plus), but imagine the same. Use the low-strength purple threadlocker to keep them from backing out. These screws are really important - the entire drive and rotational force of the stepper is transferred to the screw which then transfers it to the pulley, then the belt, etc. They are the only mechanical interface to transfer power from the stepper onward.
Interesting how many threads are related to these 5 cent screws… 